信帆生物-環(huán)指蛋白135抗體可應(yīng)用多種科研實驗

中文名稱：環(huán)指蛋白135抗體
別       名：L13; MGC13061; ring finger protein 135; RN135_HUMAN . 
研究領(lǐng)域：神經(jīng)生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  環(huán)指蛋白 
抗體來源：Rabbit
克隆類型：Polyclonal
交叉反應(yīng)：Human, Mouse, Rat, Dog, Cow,
產(chǎn)品應(yīng)用：WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量：48kDa
細(xì)胞定位：細(xì)胞漿
性    狀：Liquid
濃    度：1mg/ml
免 疫 原：KLH conjugated synthetic peptide derived from human RNF135:288-360/432
亞    型：IgG
純化方法：affinity purified by Protein A
儲 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件：Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹：The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF135 (RING finger protein 135), also known as L13, is a 432 amino acid protein that contains one RING-type zinc finger and one SPRY domain. Via its RING-type zinc finger, RNF135 may play a role in transcriptional regulation and protein degradation events. Defects in the gene encoding RNF135 are the cause of RNF135-related overgrowth syndrome which is characterized by learning disabilities, facial dysmorphism and increased weight and height. Multiple isoforms of RNF135 exist due to alternative splicing events.

Function:
The protein encoded by RNF135 contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis.

Subunit:
Interacts with DDX58. Interacts with PCBP2.

Subcellular Location:
Cytoplasmic

Tissue Specificity:
Expressed in skeletal muscle, spleen, kidney,placenta, prostate, stomach, thyroid and tongue. Also weaklyexpressed in heart, thymus, liver and lung.

Post-translational modifications:
Defects in RNF135 are the cause of macrocephalymacrosomia facial dysmorphism syndrome (MMFD) [MIM:614192]. MMFD isan autosomal dominant disorder characterized by the association ofmacrothrombocytopathy and progressive sensorineural hearing losswithout renal dysfunction.

信帆生物-環(huán)指蛋白135抗體可應(yīng)用多種科研實驗